How to switch a master switch.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 23908771.
- Also identified by DOI 10.7554/eLife.01159 and PMC identifier 3728619.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The crystal structure of a nucleotide exchange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like behaviour of the signalling protein Ras.
Medical subject headings
- DNA-Binding Proteins
- Guanine Nucleotide Exchange Factors