Highly sensitive detection of physiological spins in a microfluidic device.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23909590.
- Also identified by DOI 10.1021/nl401522a.
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Abstract
Sensing and imaging paramagnetic species under physiological conditions is a key technology in chemical and biochemical analytics, cell biology, and medical sciences. At submicrometer length scales, nitrogen-vacancy (NV) centers in diamond offer atom-sized probes for magnetic fields. We show that spin relaxation of an ensemble NV sensor allows sensing of adsorbed and freely diffusing manganese(II) ions and adsorbed ferritin. Sensitivities approach 175 Mn ions and 10 ferritin proteins per diffraction limited spot under ambient conditions.
Medical subject headings
- Diamond
- Microfluidic Analytical Techniques
- Nitrogen