Parental permissions: H19 and keeping the stem cell progeny under control.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23910078.
- Also identified by DOI 10.1016/j.stem.2013.07.008.
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Abstract
H19 is shown by Venkatraman et al. (2013), using maternal-allele-specific deletion of the differentially methylated region, to maintain hematopoietic stem cell repopulating ability through a miR-675-Igf1r signaling circuit. This work establishes function in somatic stem cells for another member of a putative imprinted gene network that may influence organismal growth.
Medical subject headings
- Adult Stem Cells
- Genomic Imprinting
- Insulin-Like Growth Factor II
- RNA, Long Noncoding