Genetic and epigenetic variations in iPSCs: potential causes and implications for application.
review · Level V
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- Record sourced from PubMed, PMID 23910082.
- Also identified by DOI 10.1016/j.stem.2013.07.001 and PMC identifier 3760008.
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Abstract
The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine. However, recent studies on the genetic and epigenetic variations in iPSCs have raised concerns that these variations may compromise the utility of iPSCs. In this Perspective, we review the current understanding of genetic and epigenetic variations in iPSCs, trace their causes, discuss the implications of these variations for iPSC applications, and propose approaches to cope with these variations.
Medical subject headings
- Epigenesis, Genetic
- Induced Pluripotent Stem Cells
- Stem Cell Transplantation