A histone modifier's ill-gotten copy gains.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23911314.
- Also identified by DOI 10.1016/j.cell.2013.07.010.
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Abstract
Little is known about the molecular machinery that contributes to site-specific copy number variations or how CNVs fit into the chronology of tumor progression. Black et al. (2013) now demonstrate that the overexpression of a histone demethylase induces transient copy gain of specific genomic loci known to harbor proto-oncogenes.
Medical subject headings
- DNA Replication
- Gene Dosage
- Jumonji Domain-Containing Histone Demethylases
- Neoplasms