Reversion and conversion of interferon-γ release assay results in HIV-1-infected individuals.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 23911707.
- Also identified by DOI 10.1093/infdis/jit418.
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Abstract
In this prospective study, human immunodeficiency virus type 1 (HIV-1)-infected subjects underwent QuantiFERON-TB Gold In-Tube interferon-γ release assay (IGRA) testing at baseline and after 24 months in a low tuberculosis incidence country. Concordant baseline and follow-up results were observed in 86% (n = 686 of 794) of subjects. IGRA conversions occurred in 9% (n = 63 of 718), whereas IGRA reversions were seen in 33% (n = 25 of 76) of individuals. Of the 10 active tuberculosis cases during follow-up, 5 had concordant positive IGRA results and 2 were IGRA converters. Although the clinical significance of IGRA conversions and reversions remains to be established, repeated IGRA testing seems to be of value in HIV-1-infected individuals.
Medical subject headings
- HIV Infections
- Interferon-gamma
- Tuberculosis