Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23913640.
- Also identified by DOI 10.1002/adma.201301338 and PMC identifier 3915041.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5β1- and αvβ3-integrins. Cells adherent via α5β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3-integrins.
Medical subject headings
- Integrin alpha5beta1
- Integrin alphaVbeta3
- Mechanical Phenomena
- Metal Nanoparticles
- Microscopy
- Peptidomimetics
- Polyethylene Glycols