p63, Sharp1, and HIFs: master regulators of metastasis in triple-negative breast cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23913939.
- Also identified by DOI 10.1158/0008-5472.CAN-13-0962.
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Abstract
Metastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior.
Medical subject headings
- Basic Helix-Loop-Helix Proteins
- Breast Neoplasms
- Hypoxia-Inducible Factor 1
- Membrane Proteins
- Triple Negative Breast Neoplasms