Acute infection induces a metastatic niche: a double menace for cancer patients.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23922303.
- Also identified by DOI 10.1158/1078-0432.CCR-13-1524 and PMC identifier 3771332.
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Abstract
Tumor-derived factors can induce a premetastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in patients with cancer. New findings reveal increased metastasis to the lung after acute bacterial infection via the CXCR4/ubiquitin axis, suggesting new targets for antimetastasis therapeutics.
Medical subject headings
- Acute Lung Injury
- Lung Neoplasms
- Receptors, CXCR4
- Ubiquitin