Systems biology: metabolite turns master regulator.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23925111.
- Also identified by DOI 10.1038/nature12544 and PMC identifier 4084598.
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Abstract
The phenomenon of catabolite repression enables microorganisms to use their favourite carbon source first. New work reveals α-ketoacids as key effectors of this process, with their levels regulating gene expression.
Medical subject headings
- Cyclic AMP
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Proteome
- Signal Transduction