Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease.
Where this comes from
- Record sourced from PubMed, PMID 23931242.
- Also identified by DOI 10.1111/acel.12125.
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Abstract
Chronic hepatitis C virus infection (C-HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C-HC have thus far been based solely on telomere length as a biomarker of aging (BoA). In this study, we have evaluated CDKN2 locus transcripts as alternative BoAs in C-HC. Our results suggest that C-HC induces non-cell-autonomous senescence and accelerates biological aging. The CDKN2 locus may provide a link between C-HC and increased susceptibility to age-associated diseases and provides novel biomarkers for assessing its impact on aging processes in man.
Medical subject headings
- Cyclin-Dependent Kinase Inhibitor p16
- Disease Progression
- Hepatitis C, Chronic
- Transcription, Genetic
- Up-Regulation