Mitochondrial dysfunction indirectly elevates ROS production by the endoplasmic reticulum.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23931748.
- Also identified by DOI 10.1016/j.cmet.2013.07.006.
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Abstract
Mitochondrial dysfunction is often associated with increased reactive oxygen species (ROS) production by the organelle itself. Leadsham et al. (2013) now show that the link between mitochondrial damage and ROS is more complicated, at least in yeast, where signals from damaged mitochondria increase ROS production from the endoplasmic reticulum surface.
Medical subject headings
- Cytochrome-c Oxidase Deficiency
- Electron Transport Complex IV
- Reactive Oxygen Species
- Saccharomyces cerevisiae
- ras Proteins