I function, therefore I am: overcoming skepticism about mitochondrial supercomplexes.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23931749.
- Also identified by DOI 10.1016/j.cmet.2013.07.010 and PMC identifier 3912836.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The mitochondrial respiratory chain is believed to dynamically arrange in suprastructures known as supercomplexes or respirasomes, though their function remains elusive. A recent study in Science (Lapuente-Brun et al., 2013) now reports that dynamic supercomplex assembly determines electron flux from different substrates through the respiratory chain.
Medical subject headings
- Cytochromes c
- Electron Transport Complex I
- Electron Transport Complex III
- Electron Transport Complex IV
- Mitochondria
- Ubiquinone