Bile acid look-alike controls life span in C. elegans.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 23931751.
- Also identified by DOI 10.1016/j.cmet.2013.07.009.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Extensive transcriptional networks maintain sterol homeostasis across species, underscoring the importance of sterol balance for healthy life. Magner et al. (2013) now show that, in C. elegans, the nuclear receptor NHR-8 is key in regulation of cholesterol balance and production of dafachronic acid, a bile acid-like steroid that controls longevity.
Medical subject headings
- Bile Acids and Salts
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cholesterol
- Lipid Metabolism
- Receptors, Cytoplasmic and Nuclear