Nemo-like kinase associated with proliferation and apoptosis by c-Myb degradation in breast cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23935942.
- Also identified by DOI 10.1371/journal.pone.0069148 and PMC identifier 3720543.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Nemo-like kinase (NLK), a mediator of the Wnt signaling pathway, binds directly to c-Myb, leading to its phosphorylation, ubiquitination and proteasome-dependent degradation. NLK was significantly downregulated in the breast cancer tissues compared to corresponding normal tissues. NLK expression was negatively correlated with c-Myb expression. NLK suppressed proliferation, induced apoptosis and mediated c-Myb degradation in MCF-7 cells via a mechanism that seems to involve c-myc and Bcl2. These findings might provide a novel target for therapeutic intervention in patients with breast cancer.
Medical subject headings
- Apoptosis
- Breast Neoplasms
- Intracellular Signaling Peptides and Proteins
- Protein Serine-Threonine Kinases
- Proteolysis
- Proto-Oncogene Proteins c-myb