Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 23935950.
- Also identified by DOI 10.1371/journal.pone.0069190 and PMC identifier 3720622.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease. A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index was calculated. Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations. The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.
Medical subject headings
- Dopaminergic Neurons
- Neuroimaging
- Parkinson Disease