Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23936094.
- Also identified by DOI 10.1371/journal.pone.0069756 and PMC identifier 3723650.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Emerging studies have indicated that microRNAs are involved in the development and progression of cancer. Here we found that miR-202-3p was frequently down-regulated in gastric cancer tissues. Overexpression of miR-202-3p in gastric cancer cells MKN-28 and BGC-823, markedly suppressed cell proliferation and induced cell apoptosis both in vitro and in vivo. Furthermore, Gli1 expression was frequently positive in gastric cancer tissues and inversely correlated with miR-133b expression. We demonstrate that the transcriptional factor Gli1 was a target of miR-202-3p and plays an essential role as a mediator of the biological effects of miR-202-3p in gastric cancer. MiR-202-3p also inhibited the expression of γ-catenin and BCL-2. Taken together, these findings suggest that miR-202-3p may function as a novel tumor suppressor in gastric cancer and its anti-tumor activity may attribute the direct targeting and inhibition of Gli1.
Medical subject headings
- Carcinoma
- Gene Expression Regulation, Neoplastic
- MicroRNAs
- Stomach Neoplasms
- Transcription Factors