Functional interaction of SCAI with the SWI/SNF complex for transcription and tumor cell invasion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23936361.
- Also identified by DOI 10.1371/journal.pone.0069947 and PMC identifier 3732290.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We have recently characterized SCAI (Suppressor of Cancer Cell Invasion), a transcriptional modulator regulating cancer cell motility through suppression of MAL/SRF dependent gene transcription. We show here that SCAI is expressed in a wide range of normal human tissues and its expression is diminished in a large array of primary human breast cancer samples indicating that SCAI expression might be linked to the etiology of human cancer. To establish a functional link between SCAI and tumorigenesis we performed affinity columns to identify SCAI-interacting proteins. Our data show that SCAI interacts with the tumor suppressing SWI/SNF chromatin remodeling complex to promote changes in gene expression and the invasive capacities of human tumor cells. Moreover our data implicate a functional hierarchy between SCAI and BRM, since SCAI function is abrogated in the absence of BRM expression.
Medical subject headings
- Breast Neoplasms
- Cell Movement
- Chromosomal Proteins, Non-Histone
- Transcription Factors
- Transcription, Genetic
- Tumor Suppressor Proteins