Caught in the act.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23936629.
- Also identified by DOI 10.7554/eLife.01127 and PMC identifier 3738094.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The crystal structure of a HECT E3 enzyme has been captured as it transfers ubiquitin to a target protein, revealing the dramatic changes in shape that enable it to modify particular residues in its targets.
Medical subject headings
- Lysine
- Ubiquitin
- Ubiquitin-Protein Ligases