Nanoparticles mimicking viral surface topography for enhanced cellular delivery.

Niu, Yuting; Yu, Meihua; Hartono, Sandy B; Yang, Jie; Xu, Hongyi; Zhang, Hongwei; Zhang, Jun; Zou, Jin et al. · Adv Mater · 2013

basic_science · Level V

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Abstract

Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20 μm).

Medical subject headings