Through thick and thin: a circulating growth factor inhibits age-related cardiac hypertrophy.
Where this comes from
- Record sourced from PubMed, PMID 23948581.
- Also identified by DOI 10.1161/CIRCRESAHA.113.302239 and PMC identifier 3800187.
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Abstract
In an intriguing new study, Loffredo et al report that joining the circulation of old mice with that of young mice reduces age-related cardiac hypertrophy. They also found that the growth factor growth/differentiation factor 11 is a circulating negative regulator of cardiac hypertrophy which suggests that raising growth/differentiation factor 11 levels may be useful to treat cardiac hypertrophy associated with aging.
Medical subject headings
- Aging
- Bone Morphogenetic Proteins
- Cardiomegaly
- Growth Differentiation Factors
- Myocytes, Cardiac
- Parabiosis