Is tumor necrosis factor-α friend or foe for chronic heart failure?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23948582.
- Also identified by DOI 10.1161/CIRCRESAHA.113.302024.
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Abstract
Although detrimental effects of tumor necrosis factor-α (TNF-α) have been reported in failing myocardium, clinical trials using TNF-α antagonists did not show the benefit of TNF-α inhibition in patients with chronic heart failure (CHF). The double-edged effects of TNF-α/Toll-like receptors (TLRs)-related proinflammatory cytokines and downstream signal transduction, nuclear factor (NF)-κB activation on failing myocardium are discussed.
Medical subject headings
- Heart Failure
- Tumor Necrosis Factor-alpha