New and TALENted genome engineering toolbox.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23948583.
- Also identified by DOI 10.1161/CIRCRESAHA.113.301765 and PMC identifier 3965580.
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Abstract
Recent advances in the burgeoning field of genome engineering are accelerating the realization of personalized therapeutics for cardiovascular disease. In the postgenomic era, sequence-specific gene-editing tools enable the functional analysis of genetic alterations implicated in disease. In partnership with high-throughput model systems, efficient gene manipulation provides an increasingly powerful toolkit to study phenotypes associated with patient-specific genetic defects. Herein, this review emphasizes the latest developments in genome engineering and how applications within the field are transforming our understanding of personalized medicine with an emphasis on cardiovascular diseases.
Medical subject headings
- Bacterial Proteins
- Cardiovascular Diseases
- Deoxyribonucleases
- Deoxyribonucleases, Type II Site-Specific
- Genetic Engineering
- Genomics
- Induced Pluripotent Stem Cells
- Mutagenesis, Site-Directed
- Precision Medicine
- Xanthomonas