Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 23951151.
- Also identified by DOI 10.1371/journal.pone.0071376 and PMC identifier 3739771.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.
Medical subject headings
- Antibodies, Viral
- HLA-DP beta-Chains
- HLA-DRB1 Chains
- Influenza Vaccines
- Influenza, Human
- Orthomyxoviridae
- Vaccination