Bumping up kinase activity with an ATP-derived neo-substrate.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23953104.
- Also identified by DOI 10.1016/j.cell.2013.07.043.
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Abstract
Pharmacologic agents capable of increasing kinase function would be useful for treating diseases associated with reduced kinase activity, such as inherited forms of Parkinson's disease. In this issue, Hertz et al. report an innovative approach for activating the Parkinson's-associated kinase PINK1 in cells with an ATP-derived neo-substrate.
Medical subject headings
- Mitochondria
- Parkinson Disease
- Protein Kinases