A cluster to remember.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23953105.
- Also identified by DOI 10.1016/j.cell.2013.07.041 and PMC identifier 3878159.
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Abstract
Based on a massive transcription factor location analysis within a single cell type, in this issue Yan et al. find that the great majority of occupancies occur within dense clusters of up to 100 factors that almost invariably contain cohesins. Retention of cohesins at cluster sites during mitosis raises the possibility that they contribute to transcriptional memory during the cell cycle.
Medical subject headings
- Cell Cycle
- Cell Cycle Proteins
- Chromosomal Proteins, Non-Histone
- Transcription Factors