Clinicopathologic significance of combined hepatocellular-cholangiocarcinoma with stem cell subtype components with reference to the expression of putative stem cell markers.
case_series · Level IV
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- Record sourced from PubMed, PMID 23955451.
- Also identified by DOI 10.1309/AJCP66AVBANVNTQJ.
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Abstract
To examine the clinicopathologic features of combined hepatocellular-cholangiocarcinoma (HC-CC), which the World Health Organization (WHO) proposed classifying into 2 types, and the expression of delta-like 1 homolog (DLK1), as well as putative stem cell markers, such as NCAM/CD56 and CD133. In this study we examined the expression of stem cell markers using immunohistochemistry. Thirty-six cases of combined HC-CC were subclassified into 24 cases, with more than 5% stem cell features (group B) and 12 cases with less than 5% stem cell areas (group A). The postoperative overall survival rate was worse for group B than for group A. DLK1 was frequently expressed in group B cases compared with group A, hepatocellular carcinoma, and intrahepatic cholangiocarcinoma cases. The 2010 WHO classification seems important for elucidating the pathogenesis of stem cell-related liver cancers.
Medical subject headings
- Antigens, CD
- Bile Duct Neoplasms
- Bile Ducts, Intrahepatic
- Carcinoma, Hepatocellular
- Cholangiocarcinoma
- Glycoproteins
- Intercellular Signaling Peptides and Proteins
- Liver Neoplasms
- Membrane Proteins
- Neural Cell Adhesion Molecules
- Peptides