Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).
basic_science · Level V
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- Record sourced from PubMed, PMID 2395870.
- Also identified by PMC identifier 54603.
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Abstract
The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines that induce perturbations in base-pair geometry. The central AGCT region of the helix has a wide (greater than 6 A) minor groove.
Medical subject headings
- Adenine
- Base Composition
- Guanine
- Nucleic Acid Conformation
- Oligodeoxyribonucleotides