Variants in HAVCR1 gene region contribute to hepatitis C persistence in African Americans.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 23964107.
- Also identified by DOI 10.1093/infdis/jit444 and PMC identifier 3883167.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
To confirm previously identified polymorphisms in HAVCR1 that were associated with persistent hepatitis C virus (HCV) infection in individuals of African and of European descent, we studied 165 subjects of African descent and 635 subjects of European descent. Because the association was only confirmed in subjects of African descent (rs6880859; odds ratio, 2.42; P = .01), we then used 379 subjects of African descent (142 with spontaneous HCV clearance) to fine-map HAVCR1. rs111511318 was strongly associated with HCV persistence after adjusting for IL28B and HLA (adjusted P = 8.8 × 10(-4)), as was one 81-kb haplotype (adjusted P = .0006). The HAVCR1 genomic region is an independent genetic determinant of HCV persistence in individuals of African descent.
Medical subject headings
- Genetic Predisposition to Disease
- Hepatitis C, Chronic
- Membrane Glycoproteins
- Receptors, Virus