Schistosomiasis japonica during pregnancy is associated with elevated endotoxin levels in maternal and placental compartments.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 23964108.
- Also identified by DOI 10.1093/infdis/jit446 and PMC identifier 3883168.
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Abstract
Schistosomiasis affects approximately 40 million women of reproductive age and has been linked to elevated levels of circulating endotoxin in nonpregnant individuals. We have evaluated endotoxin levels in maternal, placental, and newborn blood collected from women residing in Leyte, Philippines. Endotoxin levels in both maternal and placental compartments in pregnant women with schistosomiasis were 1.3- and 2.4-fold higher, respectively, than in uninfected women. In addition, higher concentrations of endotoxin in placental blood were associated with premature birth, acute chorioamnionitis, and elevated proinflammatory cytokines. By promoting endotoxemia, schistosomiasis may exert additional, maladaptive influences on pregnancy outcomes.
Medical subject headings
- Blood Chemical Analysis
- Endotoxins
- Fetal Blood
- Pregnancy Complications, Parasitic
- Schistosomiasis japonica