Mathematical model of bursting in dissociated purkinje neurons.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23967054.
- Also identified by DOI 10.1371/journal.pone.0068765 and PMC identifier 3742666.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst. The mechanism of this bursting is incompletely understood. We have constructed a biophysical Purkinje soma model, guided and constrained by experimental reports in the literature, that can replicate the somatically driven bursting pattern and which hypothesises Persistent Na(+) current (INaP) to be its burst initiator and SK K(+) current (ISK) to be its burst terminator.
Medical subject headings
- Action Potentials
- Models, Neurological
- Purkinje Cells