The effect of polyhydroxylated alkaloids on maltase-glucoamylase.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23967118.
- Also identified by DOI 10.1371/journal.pone.0070841 and PMC identifier 3742645.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
One of the most important carbohydrate-splitting enzymes is themaltase-glucoamylase which catalyzes the hydrolysis of alpha-glucosidic linkages. Maltase-glucoamylase inhibitors during the last few years have aroused medical interests in the treatment of diabetes. They contribute to a better understanding of the mechanism of maltase-glucoamylase. At present there are many different classes of maltase-glucoamylase inhibitors. This paper focuses on alkaloidal inhibitors of maltase-glucoamylase and structure-activity relationship (SAR) studies between them in order to discover some drugs with better efficiency and lower toxicity for treating diabetes.
Medical subject headings
- Alkaloids
- Enzyme Inhibitors
- alpha-Glucosidases