Discovery of the cellular and molecular basis of cholesterol control.
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- Record sourced from PubMed, PMID 23975928.
- Also identified by DOI 10.1073/pnas.1312967110 and PMC identifier 3773783.
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Abstract
The cellular control of cholesterol metabolism mediated by lipoproteins was first appreciated in pioneering work published in a 1974 PNAS Classic by Michael Brown and Joseph Goldstein. We know from this paper that the LDL binds to a cell surface receptor and dampens the activity of a key enzyme in cholesterol biosynthesis and that a receptor deficiency is responsible for a major genetic cause of hypercholesterolemia and premature atherosclerosis.
Medical subject headings
- Cholesterol