Think modular: a simple apoferritin-based platform for the multifaceted detection of pancreatic cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23988226.
- Also identified by DOI 10.1021/nn403465a.
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Abstract
The generation of nanosized probes often requires time-intensive and application-specific optimization processes that involve conjugating a nanoconstruct to a targeting moiety. Herein, we genetically modify apoferritin and generate a universal interface system composed of protein G and 6×His-tag. The resulting construct, conferred with modularity and high targeting efficiency, is applied toward two distinct applications in the detection of a pancreatic cancer biomarker and used to demonstrate its potential in the facile exchange of nanoprobe components.
Medical subject headings
- Apoferritins
- Biosensing Techniques
- Claudin-4
- Pancreatic Neoplasms
- Quantum Dots
- Spectrometry, Fluorescence