Tissue protection by erythropoietin: new findings in a moving field.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23989353.
- Also identified by DOI 10.1038/ki.2013.140.
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Abstract
Two groups elucidate novel mechanisms of tissue protection by erythropoietin (EPO). Hu et al. demonstrate that Klotho's protective effect against oxidant-induced cytotoxicity is partially mediated by an increase in the endogenous expression of the classical EPO receptor (EpoR). While erythropoiesis is stimulated by the canonical EpoR homodimer, the tissue-protective effects of EPO are mediated through a heterodimeric 'tissue-protective' receptor. Coldewey et al. demonstrate a protective role of the 'tissue-protective' EpoR against acute kidney injury.
Medical subject headings
- Acute Kidney Injury
- Cytokine Receptor Common beta Subunit
- Cytoprotection
- Erythropoietin
- Glucuronidase
- Kidney
- Receptors, Erythropoietin
- Sepsis