Genotypic variation and outcomes in kidney transplantation: donor and recipient effects.
Where this comes from
- Record sourced from PubMed, PMID 23989355.
- Also identified by DOI 10.1038/ki.2013.167 and PMC identifier 3761401.
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Abstract
The genetic composition of a donor impacts long-term allograft survival after kidney transplantation. Effects of the recipient's genetic make-up, particularly variation in immune response pathway genes, are less certain. Bay et al. reveal improved graft survival in transplant recipients with lower copy numbers of the complement 4 gene (C4) after receipt of deceased-donor kidneys. Genomics breakthroughs in nephrology and immunology will likely revolutionize the field of transplant medicine.
Medical subject headings
- Complement C4
- Gene Dosage
- Graft Survival
- Kidney Transplantation
- Tissue Donors