Unexpected effect of the appetite-stimulating hormone ghrelin on ENaC: hunger for sodium?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23989358.
- Also identified by DOI 10.1038/ki.2013.141.
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Abstract
The orexigenic hormone ghrelin acts like a hunger signal, released by the stomach in response to nutritional status. However, ghrelin and its receptor in the kidney may play other biological roles. Kemp and colleagues identify that ghrelin stimulates renal Na+ absorption through cAMP-dependent trafficking of ENaC in the cortical collecting duct. While ghrelin seems to be a physiological regulator of ENaC, future studies are necessary to clarify its physiological and pathological roles in sodium homeostasis.
Medical subject headings
- Cyclic AMP
- Epithelial Sodium Channels
- Kidney Tubules, Collecting
- Receptors, Ghrelin
- Signal Transduction
- Sodium