TALENoffer: genome-wide TALEN off-target prediction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23995255.
- Also identified by DOI 10.1093/bioinformatics/btt501.
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Abstract
Transcription activator-like effector nucleases (TALENs) have become an accepted tool for targeted mutagenesis, but undesired off-targets remain an important issue. We present TALENoffer, a novel tool for the genome-wide prediction of TALEN off-targets. We show that TALENoffer successfully predicts known off-targets of engineered TALENs and yields a competitive runtime, scanning complete mammalian genomes within a few minutes. TALENoffer is available as a command line program from http://www.jstacs.de/index.php/TALENoffer and as a Galaxy server at http://galaxy.informatik.uni-halle.de. grau@informatik.uni-halle.de
Medical subject headings
- Endodeoxyribonucleases
- Software