Tracking adipogenesis during white adipose tissue development, expansion and regeneration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23995282.
- Also identified by DOI 10.1038/nm.3324 and PMC identifier 4075943.
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Abstract
White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HFD) feeding and cold exposure. During cold-induced 'browning' of subcutaneous fat, most 'beige' adipocytes stem from de novo-differentiated adipocytes. During HFD feeding, epididymal fat initiates adipogenesis after 4 weeks, whereas subcutaneous fat undergoes hypertrophy for a period of up to 12 weeks. Gonadal fat develops postnatally, whereas subcutaneous fat develops between embryonic days 14 and 18. Our results highlight the extensive differences in adipogenic potential in various fat depots.
Medical subject headings
- Adipogenesis
- Adipose Tissue, White