Controlled cell adhesion on poly(dopamine) interfaces photopatterned with non-fouling brushes.

Rodriguez-Emmenegger, Cesar; Preuss, Corinna M; Yameen, Basit; Pop-Georgievski, Ognen; Bachmann, Michael; Mueller, Jan O; Bruns, Michael; Goldmann, Anja S et al. · Adv Mater · 2013

basic_science · Level V

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Abstract

Bioinspired poly(dopamine) (PDA) films are merged with antifouling poly(MeOEGMA) brushes utilizing a nitrile imine-mediated tetrazole-ene cycloaddition (NITEC)-based phototriggered surface encoding protocol. The antifouling brushes were photopatterned on PDA surfaces, leading cells to form confluent layers in the non-irradiated sections, while no adhesion occurred on the brushes resulting in a remarkably precise cell pattern. The presented strategy paves the way for the design of tailor-made patterned cell interfaces.

Medical subject headings