Coamplification and cooperation: toward identifying biologically relevant oncogenes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24004673.
- Also identified by DOI 10.1158/1078-0432.CCR-13-2117 and PMC identifier 4147724.
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Abstract
Identification of biologically relevant genes from genomic assays is limited by the complexity of changes present in most solid tumors. Assessing for coactivation of functionally related genes resulted in the identification of SENP2, DCUN1D1, and DVL3--consensus candidates that drive selection for 3q amplification in lung squamous cell carcinomas.
Medical subject headings
- Carcinoma, Squamous Cell
- Chromosomes, Human, Pair 3
- Gene Amplification
- Genomics
- Lung Neoplasms
- Oncogenes