Female predominance of immune response to SSA/Ro antigens and risk of neonatal lupus erythematosus.
case_report · Level V
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Abstract
Eight-hundred and twenty-five patients attending the hospital with clinical signs and symptoms of collagen diseases were tested for anti-SSA/Ro antibody. The frequency of positivity to SSA/Ro was significantly higher in females, 11.0%, than in males, 3.2% (P less than 0.01). Five babies born to anti-SSA/Ro positive mothers all had neonatal lupus erythematosus and in one there were various cardiac abnormalities.
Medical subject headings
- Antibodies, Antinuclear
- Lupus Erythematosus, Systemic
- RNA, Small Cytoplasmic
- Ribonucleoproteins