Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a.
basic_science · Level V
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- Record sourced from PubMed, PMID 24009392.
- Also identified by DOI 10.1126/science.1239864.
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Abstract
Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.
Medical subject headings
- Epigenesis, Genetic
- Gene Expression Regulation, Developmental
- Histones
- Jumonji Domain-Containing Histone Demethylases
- Protein Processing, Post-Translational
- Sex Determination Processes