Leptin, GABA, and glucose control.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 24011066.
- Also identified by DOI 10.1016/j.cmet.2013.08.015 and PMC identifier 4097301.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Leptin mimics many of the antidiabetic actions of insulin in insulin-deficient diabetes, but the mechanism is controversial. Fujikawa et al. (2013) reveal that leptin receptors in γ-aminobutyric acid (GABA)-ergic and pro-opiomelanocortin (POMC) neurons in the central nervous system are sufficient to mediate the lifesaving and antidiabetic actions of leptin in insulin-deficient mice.
Medical subject headings
- Hypothalamus
- Insulin
- Leptin
- Neurons