FGF21 mimetic shows therapeutic promise.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 24011067.
- Also identified by DOI 10.1016/j.cmet.2013.08.014 and PMC identifier 3789140.
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Abstract
FGF21 is a protein with multiple metabolic actions, currently a bright star beckoning on the metabolic disease therapeutic horizon. Gaich et al. (2013) present the first clinical efficacy trial for an FGF21 mimetic, finding robust lipid-lowering effects, some reduction in body weight, but surprisingly modest effects on glucose homeostasis.
Medical subject headings
- Diabetes Mellitus, Type 2
- Fibroblast Growth Factors
- Obesity