Sinister symbiosis: pathological hematopoietic-stromal interactions in CML.
editorial · Level V
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- Record sourced from PubMed, PMID 24012363.
- Also identified by DOI 10.1016/j.stem.2013.08.009 and PMC identifier 3842099.
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Abstract
The impact of myeloid malignancies on the nonhematopoietic components of the bone marrow remains poorly understood. In this issue of Cell Stem Cell, Schepers et al. (2013) describe how malignant myeloid cells alter the endosteal hematopoietic stem cell (HSC) niche, resulting in the expansion of osteoblastic lineage cells that preferentially support malignant HSCs.
Medical subject headings
- Bone Marrow
- Leukemia
- Mesenchymal Stem Cells
- Myeloproliferative Disorders
- Neoplastic Stem Cells
- Primary Myelofibrosis
- Stem Cell Niche