Breaking the canon: indirect regulation of Wnt signaling in mammary stem cells by MMP3.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24012364.
- Also identified by DOI 10.1016/j.stem.2013.08.008.
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Abstract
Matrix metalloproteases promote tumor cell invasion, epithelial-to-mesenchymal transitions, and metastases, but whether they directly regulate stem cells is unknown. In this issue of Cell Stem Cell, Kessenbrock et al. (2013) now show that MMP3, independent of its proteolytic activity, regulates murine mammary stem cells by sequestering noncanonical Wnt signaling ligands, which has implications for breast cancer pathogenesis.
Medical subject headings
- Adult Stem Cells
- Epithelium
- Mammary Glands, Animal
- Matrix Metalloproteinase 3
- Wnt Proteins