And then there were none: no need for pluripotency factors to induce reprogramming.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24012365.
- Also identified by DOI 10.1016/j.stem.2013.08.004 and PMC identifier 4659384.
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Abstract
While most factors used as reprogramming transgenes can be replaced by other means, Oct4 has remained essential until now. Three recent papers have now broken this barrier through the use of opposing lineage specifying transgenes and chemical modulation, thus signifying a milestone in advancing our understanding of pluripotency induction.
Medical subject headings
- Cell Dedifferentiation
- Cell Engineering
- Cellular Reprogramming
- Fibroblasts
- GATA3 Transcription Factor
- Induced Pluripotent Stem Cells
- Octamer Transcription Factor-3
- Pluripotent Stem Cells
- Small Molecule Libraries
- Transcription Factors