Alzheimer's and prion diseases: PDK1 at the crossroads.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24013743.
- Also identified by DOI 10.1038/nm.3332.
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Abstract
TACE-mediated proteolysis is a key event interfering with both Alzheimer's and prion diseases. A new study shows that phosphoinositide-dependent kinase-1 (PDK1) is activated by cellular prion protein, which alters membrane-associated TACE levels, thereby influencing both Alzheimer's and prion pathologies.
Medical subject headings
- ADAM Proteins
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Prion Diseases
- Protein Serine-Threonine Kinases