Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24015274.
- Also identified by DOI 10.1371/journal.pone.0072767 and PMC identifier 3755970.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key moments of post-natal development, and along the adult spermatogenic cycle. Notch pathway components and effectors are transcribed in the testis and expressed in germ, Sertoli and Leydig cells, and each Notch component shows a specific cell-type and time-window expression pattern. This expression at key testis developmental events prompt for a role of Notch signaling in pre-pubertal spermatogonia quiescence, onset of spermatogenesis, and regulation of the spermatogenic cycle.
Medical subject headings
- Gene Expression Regulation
- Receptors, Notch
- Signal Transduction
- Spermatogenesis
- Testis
- Transcription, Genetic